Cancer-miRNA Regulatory Network

Compendium of miRNA Target Genes

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GCT Seminoma Korkola Cluster Number 102 (94 genes) This page contains all miRNA mediated regulation and functional enrichment for GCT Seminoma Korkola cluster number 102. Information about seminoma can be found on Wikipedia, and further information about the "GCT Seminoma Korkola" dataset can be found in Korkola et al., 2006. Inferred miRNA Mediated Regulation Weeder-miRvestigator PITA TargetScan zzz999 hsa-mir-125a-5p hsa-mir-125b hsa-mir-34a Gene Ontology Enrichment GO ID GO Term Annotated Genes in Cluster GO:0001775 cell activation 19 GO:0001906 cell killing 5 GO:0001909 leukocyte mediated cytotoxicity 4 GO:0002252 immune effector process 13 GO:0002376 immune system process 36 GO:0002443 leukocyte mediated immunity 9 GO:0002449 lymphocyte mediated immunity 7 GO:0002520 immune system development 10 GO:0002682 regulation of immune system process 21 GO:0002684 positive regulation of immune system process 16 GO:0002694 regulation of leukocyte activation 12 GO:0002696 positive regulation of leukocyte activation 10 GO:0002697 regulation of immune effector process 9 GO:0002699 positive regulation of immune effector process 6 GO:0002703 regulation of leukocyte mediated immunity 6 GO:0002706 regulation of lymphocyte mediated immunity 5 GO:0002715 regulation of natural killer cell mediated immunity 3 GO:0002717 positive regulation of natural killer cell mediated immunity 3 GO:0006952 defense response 18 GO:0006955 immune response 29 GO:0007165 signal transduction 42 GO:0007166 cell surface receptor linked signaling pathway 31 GO:0031341 regulation of cell killing 4 GO:0031343 positive regulation of cell killing 4 GO:0032943 mononuclear cell proliferation 7 GO:0032944 regulation of mononuclear cell proliferation 7 GO:0032946 positive regulation of mononuclear cell proliferation 5 GO:0042098 T cell proliferation 5 GO:0042102 positive regulation of T cell proliferation 4 GO:0042110 T cell activation 12 GO:0042129 regulation of T cell proliferation 5 GO:0042269 regulation of natural killer cell mediated cytotoxicity 3 GO:0043366 beta selection 2 GO:0045087 innate immune response 12 GO:0045321 leukocyte activation 16 GO:0045954 positive regulation of natural killer cell mediated cytotoxicity 3 GO:0046631 alpha-beta T cell activation 4 GO:0046633 alpha-beta T cell proliferation 3 GO:0046634 regulation of alpha-beta T cell activation 4 GO:0046640 regulation of alpha-beta T cell proliferation 3 GO:0046649 lymphocyte activation 16 GO:0046651 lymphocyte proliferation 7 GO:0048518 positive regulation of biological process 30 GO:0048583 regulation of response to stimulus 31 GO:0050670 regulation of lymphocyte proliferation 7 GO:0050671 positive regulation of lymphocyte proliferation 5 GO:0050776 regulation of immune response 14 GO:0050778 positive regulation of immune response 8 GO:0050789 regulation of biological process 63 GO:0050794 regulation of cellular process 59 GO:0050863 regulation of T cell activation 10 GO:0050865 regulation of cell activation 12 GO:0050867 positive regulation of cell activation 10 GO:0050870 positive regulation of T cell activation 8 GO:0050896 response to stimulus 60 GO:0051249 regulation of lymphocyte activation 12 GO:0051251 positive regulation of lymphocyte activation 10 GO:0065007 biological regulation 64 Overlap Between miRNA Target Genes and Enriched Gene Ontology Annotations miRNA Method GO ID GO Term Overlap GO Annotated Genes Cluster Size miRNA Targets Genes P-Value hsa-mir-34a TargetScan GO:0001775 cell activation 6 19 94 23 0.1352479 hsa-mir-125a-5p PITA GO:0001775 cell activation 0 19 94 8 0.8484387 hsa-mir-125b PITA GO:0001775 cell activation 0 19 94 8 0.8484387 hsa-mir-34a TargetScan GO:0001906 cell killing 0 5 94 23 0.7628044 hsa-mir-125a-5p PITA GO:0001906 cell killing 0 5 94 8 0.3655373 hsa-mir-125b PITA GO:0001906 cell killing 0 5 94 8 0.3655373 hsa-mir-34a TargetScan GO:0001909 leukocyte mediated cytotoxicity 0 4 94 23 0.681379 hsa-mir-125a-5p PITA GO:0001909 leukocyte mediated cytotoxicity 0 4 94 8 0.3036385 hsa-mir-125b PITA GO:0001909 leukocyte mediated cytotoxicity 0 4 94 8 0.3036385 hsa-mir-34a TargetScan GO:0002252 immune effector process 2 13 94 23 0.6678877 hsa-mir-125a-5p PITA GO:0002252 immune effector process 0 13 94 8 0.7110521 hsa-mir-125b PITA GO:0002252 immune effector process 0 13 94 8 0.7110521 hsa-mir-34a TargetScan GO:0002376 immune system process 9 36 94 23 0.3633875 hsa-mir-125a-5p PITA GO:0002376 immune system process 1 36 94 8 0.8855405 hsa-mir-125b PITA GO:0002376 immune system process 1 36 94 8 0.8855405 hsa-mir-34a TargetScan GO:0002443 leukocyte mediated immunity 0 9 94 23 0.9299845 hsa-mir-125a-5p PITA GO:0002443 leukocyte mediated immunity 0 9 94 8 0.567673 hsa-mir-125b PITA GO:0002443 leukocyte mediated immunity 0 9 94 8 0.567673 hsa-mir-34a TargetScan GO:0002449 lymphocyte mediated immunity 0 7 94 23 0.8700754 hsa-mir-125a-5p PITA GO:0002449 lymphocyte mediated immunity 0 7 94 8 0.4750615 hsa-mir-125b PITA GO:0002449 lymphocyte mediated immunity 0 7 94 8 0.4750615 hsa-mir-34a TargetScan GO:0002520 immune system development 4 10 94 23 0.06099596 hsa-mir-125a-5p PITA GO:0002520 immune system development 1 10 94 8 0.2014665 hsa-mir-125b PITA GO:0002520 immune system development 1 10 94 8 0.2014665 hsa-mir-34a TargetScan GO:0002682 regulation of immune system process 6 21 94 23 0.2134639 hsa-mir-125a-5p PITA GO:0002682 regulation of immune system process 1 21 94 8 0.5718599 hsa-mir-125b PITA GO:0002682 regulation of immune system process 1 21 94 8 0.5718599 hsa-mir-34a TargetScan GO:0002684 positive regulation of immune system process 5 16 94 23 0.1554815 hsa-mir-125a-5p PITA GO:0002684 positive regulation of immune system process 0 16 94 8 0.7893647 hsa-mir-125b PITA GO:0002684 positive regulation of immune system process 0 16 94 8 0.7893647 hsa-mir-34a TargetScan GO:0002694 regulation of leukocyte activation 5 12 94 23 0.03806047 hsa-mir-125a-5p PITA GO:0002694 regulation of leukocyte activation 0 12 94 8 0.6798145 hsa-mir-125b PITA GO:0002694 regulation of leukocyte activation 0 12 94 8 0.6798145 hsa-mir-34a TargetScan GO:0002696 positive regulation of leukocyte activation 4 10 94 23 0.06099596 hsa-mir-125a-5p PITA GO:0002696 positive regulation of leukocyte activation 0 10 94 8 0.6083626 hsa-mir-125b PITA GO:0002696 positive regulation of leukocyte activation 0 10 94 8 0.6083626 hsa-mir-34a TargetScan GO:0002697 regulation of immune effector process 1 9 94 23 0.6999336 hsa-mir-125a-5p PITA GO:0002697 regulation of immune effector process 0 9 94 8 0.567673 hsa-mir-125b PITA GO:0002697 regulation of immune effector process 0 9 94 8 0.567673 hsa-mir-34a TargetScan GO:0002699 positive regulation of immune effector process 0 6 94 23 0.8241021 hsa-mir-125a-5p PITA GO:0002699 positive regulation of immune effector process 0 6 94 8 0.4225677 hsa-mir-125b PITA GO:0002699 positive regulation of immune effector process 0 6 94 8 0.4225677 hsa-mir-34a TargetScan GO:0002703 regulation of leukocyte mediated immunity 0 6 94 23 0.8241021 hsa-mir-125a-5p PITA GO:0002703 regulation of leukocyte mediated immunity 0 6 94 8 0.4225677 hsa-mir-125b PITA GO:0002703 regulation of leukocyte mediated immunity 0 6 94 8 0.4225677 hsa-mir-34a TargetScan GO:0002706 regulation of lymphocyte mediated immunity 0 5 94 23 0.7628044 hsa-mir-125a-5p PITA GO:0002706 regulation of lymphocyte mediated immunity 0 5 94 8 0.3655373 hsa-mir-125b PITA GO:0002706 regulation of lymphocyte mediated immunity 0 5 94 8 0.3655373 hsa-mir-34a TargetScan GO:0002715 regulation of natural killer cell mediated immunity 0 3 94 23 0.5736102 hsa-mir-125a-5p PITA GO:0002715 regulation of natural killer cell mediated immunity 0 3 94 8 0.2365194 hsa-mir-125b PITA GO:0002715 regulation of natural killer cell mediated immunity 0 3 94 8 0.2365194 hsa-mir-34a TargetScan GO:0002717 positive regulation of natural killer cell mediated immunity 0 3 94 23 0.5736102 hsa-mir-125a-5p PITA GO:0002717 positive regulation of natural killer cell mediated immunity 0 3 94 8 0.2365194 hsa-mir-125b PITA GO:0002717 positive regulation of natural killer cell mediated immunity 0 3 94 8 0.2365194 hsa-mir-34a TargetScan GO:0006952 defense response 4 18 94 23 0.4636897 hsa-mir-125a-5p PITA GO:0006952 defense response 0 18 94 8 0.830608 hsa-mir-125b PITA GO:0006952 defense response 0 18 94 8 0.830608 hsa-mir-34a TargetScan GO:0006955 immune response 5 29 94 23 0.7945375 hsa-mir-125a-5p PITA GO:0006955 immune response 1 29 94 8 0.773284 hsa-mir-125b PITA GO:0006955 immune response 1 29 94 8 0.773284 hsa-mir-34a TargetScan GO:0007165 signal transduction 12 42 94 23 0.1417327 hsa-mir-125a-5p PITA GO:0007165 signal transduction 3 42 94 8 0.51726 hsa-mir-125b PITA GO:0007165 signal transduction 3 42 94 8 0.51726 hsa-mir-34a TargetScan GO:0007166 cell surface receptor linked signaling pathway 8 31 94 23 0.3164146 hsa-mir-125a-5p PITA GO:0007166 cell surface receptor linked signaling pathway 2 31 94 8 0.5272971 hsa-mir-125b PITA GO:0007166 cell surface receptor linked signaling pathway 2 31 94 8 0.5272971 hsa-mir-34a TargetScan GO:0031341 regulation of cell killing 0 4 94 23 0.681379 hsa-mir-125a-5p PITA GO:0031341 regulation of cell killing 0 4 94 8 0.3036385 hsa-mir-125b PITA GO:0031341 regulation of cell killing 0 4 94 8 0.3036385 hsa-mir-34a TargetScan GO:0031343 positive regulation of cell killing 0 4 94 23 0.681379 hsa-mir-125a-5p PITA GO:0031343 positive regulation of cell killing 0 4 94 8 0.3036385 hsa-mir-125b PITA GO:0031343 positive regulation of cell killing 0 4 94 8 0.3036385 hsa-mir-34a TargetScan GO:0032943 mononuclear cell proliferation 3 7 94 23 0.05833777 hsa-mir-125a-5p PITA GO:0032943 mononuclear cell proliferation 0 7 94 8 0.4750615 hsa-mir-125b PITA GO:0032943 mononuclear cell proliferation 0 7 94 8 0.4750615 hsa-mir-34a TargetScan GO:0032944 regulation of mononuclear cell proliferation 3 7 94 23 0.05833777 hsa-mir-125a-5p PITA GO:0032944 regulation of mononuclear cell proliferation 0 7 94 8 0.4750615 hsa-mir-125b PITA GO:0032944 regulation of mononuclear cell proliferation 0 7 94 8 0.4750615 hsa-mir-34a TargetScan GO:0032946 positive regulation of mononuclear cell proliferation 2 5 94 23 0.09224258 hsa-mir-125a-5p PITA GO:0032946 positive regulation of mononuclear cell proliferation 0 5 94 8 0.3655373 hsa-mir-125b PITA GO:0032946 positive regulation of mononuclear cell proliferation 0 5 94 8 0.3655373 hsa-mir-34a TargetScan GO:0042098 T cell proliferation 3 5 94 23 0.01206671 hsa-mir-125a-5p PITA GO:0042098 T cell proliferation 0 5 94 8 0.3655373 hsa-mir-125b PITA GO:0042098 T cell proliferation 0 5 94 8 0.3655373 hsa-mir-34a TargetScan GO:0042102 positive regulation of T cell proliferation 2 4 94 23 0.04413706 hsa-mir-125a-5p PITA GO:0042102 positive regulation of T cell proliferation 0 4 94 8 0.3036385 hsa-mir-125b PITA GO:0042102 positive regulation of T cell proliferation 0 4 94 8 0.3036385 hsa-mir-34a TargetScan GO:0042110 T cell activation 5 12 94 23 0.03806047 hsa-mir-125a-5p PITA GO:0042110 T cell activation 0 12 94 8 0.6798145 hsa-mir-125b PITA GO:0042110 T cell activation 0 12 94 8 0.6798145 hsa-mir-34a TargetScan GO:0042129 regulation of T cell proliferation 3 5 94 23 0.01206671 hsa-mir-125a-5p PITA GO:0042129 regulation of T cell proliferation 0 5 94 8 0.3655373 hsa-mir-125b PITA GO:0042129 regulation of T cell proliferation 0 5 94 8 0.3655373 hsa-mir-34a TargetScan GO:0042269 regulation of natural killer cell mediated cytotoxicity 0 3 94 23 0.5736102 hsa-mir-125a-5p PITA GO:0042269 regulation of natural killer cell mediated cytotoxicity 0 3 94 8 0.2365194 hsa-mir-125b PITA GO:0042269 regulation of natural killer cell mediated cytotoxicity 0 3 94 8 0.2365194 hsa-mir-34a TargetScan GO:0043366 beta selection 0 2 94 23 0.4314802 hsa-mir-125a-5p PITA GO:0043366 beta selection 0 2 94 8 0.1638069 hsa-mir-125b PITA GO:0043366 beta selection 0 2 94 8 0.1638069 hsa-mir-34a TargetScan GO:0045087 innate immune response 1 12 94 23 0.8498662 hsa-mir-125a-5p PITA GO:0045087 innate immune response 0 12 94 8 0.6798145 hsa-mir-125b PITA GO:0045087 innate immune response 0 12 94 8 0.6798145 hsa-mir-34a TargetScan GO:0045321 leukocyte activation 5 16 94 23 0.1554815 hsa-mir-125a-5p PITA GO:0045321 leukocyte activation 0 16 94 8 0.7893647 hsa-mir-125b PITA GO:0045321 leukocyte activation 0 16 94 8 0.7893647 hsa-mir-34a TargetScan GO:0045954 positive regulation of natural killer cell mediated cytotoxicity 0 3 94 23 0.5736102 hsa-mir-125a-5p PITA GO:0045954 positive regulation of natural killer cell mediated cytotoxicity 0 3 94 8 0.2365194 hsa-mir-125b PITA GO:0045954 positive regulation of natural killer cell mediated cytotoxicity 0 3 94 8 0.2365194 hsa-mir-34a TargetScan GO:0046631 alpha-beta T cell activation 2 4 94 23 0.04413706 hsa-mir-125a-5p PITA GO:0046631 alpha-beta T cell activation 0 4 94 8 0.3036385 hsa-mir-125b PITA GO:0046631 alpha-beta T cell activation 0 4 94 8 0.3036385 hsa-mir-34a TargetScan GO:0046633 alpha-beta T cell proliferation 1 3 94 23 0.1472203 hsa-mir-125a-5p PITA GO:0046633 alpha-beta T cell proliferation 0 3 94 8 0.2365194 hsa-mir-125b PITA GO:0046633 alpha-beta T cell proliferation 0 3 94 8 0.2365194 hsa-mir-34a TargetScan GO:0046634 regulation of alpha-beta T cell activation 2 4 94 23 0.04413706 hsa-mir-125a-5p PITA GO:0046634 regulation of alpha-beta T cell activation 0 4 94 8 0.3036385 hsa-mir-125b PITA GO:0046634 regulation of alpha-beta T cell activation 0 4 94 8 0.3036385 hsa-mir-34a TargetScan GO:0046640 regulation of alpha-beta T cell proliferation 1 3 94 23 0.1472203 hsa-mir-125a-5p PITA GO:0046640 regulation of alpha-beta T cell proliferation 0 3 94 8 0.2365194 hsa-mir-125b PITA GO:0046640 regulation of alpha-beta T cell proliferation 0 3 94 8 0.2365194 hsa-mir-34a TargetScan GO:0046649 lymphocyte activation 5 16 94 23 0.1554815 hsa-mir-125a-5p PITA GO:0046649 lymphocyte activation 0 16 94 8 0.7893647 hsa-mir-125b PITA GO:0046649 lymphocyte activation 0 16 94 8 0.7893647 hsa-mir-34a TargetScan GO:0046651 lymphocyte proliferation 3 7 94 23 0.05833777 hsa-mir-125a-5p PITA GO:0046651 lymphocyte proliferation 0 7 94 8 0.4750615 hsa-mir-125b PITA GO:0046651 lymphocyte proliferation 0 7 94 8 0.4750615 hsa-mir-34a TargetScan GO:0048518 positive regulation of biological process 8 30 94 23 0.2721681 hsa-mir-125a-5p PITA GO:0048518 positive regulation of biological process 2 30 94 8 0.4998296 hsa-mir-125b PITA GO:0048518 positive regulation of biological process 2 30 94 8 0.4998296 hsa-mir-34a TargetScan GO:0048583 regulation of response to stimulus 8 31 94 23 0.3164146 hsa-mir-125a-5p PITA GO:0048583 regulation of response to stimulus 2 31 94 8 0.5272971 hsa-mir-125b PITA GO:0048583 regulation of response to stimulus 2 31 94 8 0.5272971 hsa-mir-34a TargetScan GO:0050670 regulation of lymphocyte proliferation 3 7 94 23 0.05833777 hsa-mir-125a-5p PITA GO:0050670 regulation of lymphocyte proliferation 0 7 94 8 0.4750615 hsa-mir-125b PITA GO:0050670 regulation of lymphocyte proliferation 0 7 94 8 0.4750615 hsa-mir-34a TargetScan GO:0050671 positive regulation of lymphocyte proliferation 2 5 94 23 0.09224258 hsa-mir-125a-5p PITA GO:0050671 positive regulation of lymphocyte proliferation 0 5 94 8 0.3655373 hsa-mir-125b PITA GO:0050671 positive regulation of lymphocyte proliferation 0 5 94 8 0.3655373 hsa-mir-34a TargetScan GO:0050776 regulation of immune response 2 14 94 23 0.7236454 hsa-mir-125a-5p PITA GO:0050776 regulation of immune response 0 14 94 8 0.7395902 hsa-mir-125b PITA GO:0050776 regulation of immune response 0 14 94 8 0.7395902 hsa-mir-34a TargetScan GO:0050778 positive regulation of immune response 1 8 94 23 0.6296403 hsa-mir-125a-5p PITA GO:0050778 positive regulation of immune response 0 8 94 8 0.5233317 hsa-mir-125b PITA GO:0050778 positive regulation of immune response 0 8 94 8 0.5233317 hsa-mir-34a TargetScan GO:0050789 regulation of biological process 17 63 94 23 0.143152 hsa-mir-125a-5p PITA GO:0050789 regulation of biological process 4 63 94 8 0.7565339 hsa-mir-125b PITA GO:0050789 regulation of biological process 4 63 94 8 0.7565339 hsa-mir-34a TargetScan GO:0050794 regulation of cellular process 17 59 94 23 0.06168612 hsa-mir-125a-5p PITA GO:0050794 regulation of cellular process 4 59 94 8 0.6623874 hsa-mir-125b PITA GO:0050794 regulation of cellular process 4 59 94 8 0.6623874 hsa-mir-34a TargetScan GO:0050863 regulation of T cell activation 5 10 94 23 0.01253954 hsa-mir-125a-5p PITA GO:0050863 regulation of T cell activation 0 10 94 8 0.6083626 hsa-mir-125b PITA GO:0050863 regulation of T cell activation 0 10 94 8 0.6083626 hsa-mir-34a TargetScan GO:0050865 regulation of cell activation 5 12 94 23 0.03806047 hsa-mir-125a-5p PITA GO:0050865 regulation of cell activation 0 12 94 8 0.6798145 hsa-mir-125b PITA GO:0050865 regulation of cell activation 0 12 94 8 0.6798145 hsa-mir-34a TargetScan GO:0050867 positive regulation of cell activation 4 10 94 23 0.06099596 hsa-mir-125a-5p PITA GO:0050867 positive regulation of cell activation 0 10 94 8 0.6083626 hsa-mir-125b PITA GO:0050867 positive regulation of cell activation 0 10 94 8 0.6083626 hsa-mir-34a TargetScan GO:0050870 positive regulation of T cell activation 4 8 94 23 0.01969148 hsa-mir-125a-5p PITA GO:0050870 positive regulation of T cell activation 0 8 94 8 0.5233317 hsa-mir-125b PITA GO:0050870 positive regulation of T cell activation 0 8 94 8 0.5233317 hsa-mir-34a TargetScan GO:0050896 response to stimulus 14 60 94 23 0.5406246 hsa-mir-125a-5p PITA GO:0050896 response to stimulus 5 60 94 8 0.3932575 hsa-mir-125b PITA GO:0050896 response to stimulus 5 60 94 8 0.3932575 hsa-mir-34a TargetScan GO:0051249 regulation of lymphocyte activation 5 12 94 23 0.03806047 hsa-mir-125a-5p PITA GO:0051249 regulation of lymphocyte activation 0 12 94 8 0.6798145 hsa-mir-125b PITA GO:0051249 regulation of lymphocyte activation 0 12 94 8 0.6798145 hsa-mir-34a TargetScan GO:0051251 positive regulation of lymphocyte activation 4 10 94 23 0.06099596 hsa-mir-125a-5p PITA GO:0051251 positive regulation of lymphocyte activation 0 10 94 8 0.6083626 hsa-mir-125b PITA GO:0051251 positive regulation of lymphocyte activation 0 10 94 8 0.6083626 hsa-mir-34a TargetScan GO:0065007 biological regulation 18 64 94 23 0.06855877 hsa-mir-125a-5p PITA GO:0065007 biological regulation 4 64 94 8 0.7782596 hsa-mir-125b PITA GO:0065007 biological regulation 4 64 94 8 0.7782596

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